News from our division
MES-3 is C. elegans SUZ12
Sensitive similarity searches and structure prediction unearthed that MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12.
Read the paper here
C. elegans Crumbs complex composition
Congratulations to Victoria Garcia on her paper describing the composition of the C. elegans Crumbs complex!
Read the paper here
Playing with the trouble
Suzan Ruijtenberg received a grant from the Centre for Unusual Collaborations (Cuco). Together with an inter-disciplinary team of nine researchers, Suzan will co-create a toolbox of modular mini-games that can support interdisciplinary collaborations and education.
Redundant control of lumen morphogenesis in C. elegans
Congratulations Jorian on the first paper in 2022! We show that ERM-1 phosphorylation and binding to NRFL-1 NHERF1/EBP50 redundantly control intestinal morphology.
Read the paper here
Generation of mixed murine organoids
Ana's recent publication in STAR Protocols describes the generation of mixed murine organoids which can be used to model cellular interactions. Congratulations Ana!
Read the paper here
LET-413 Scribble is essential in larval epithelia
Amalia's recent publication in PLOS Genetics shows that LET-413 Scribble is essential in the epidermis for animal development, and for directed outgrowth of the seam cells. Congratulations Amalia!
Read the paper here
Fluorescence-based protein–protein interaction assay
Jason's paper in Genetics presents C. elegans light-induced coclustering (CeLINC), an optical binary protein–protein interaction assay to determine whether two proteins interact in vivo.
Read the paper here
Welcome Saskia!
We are proud to welcome Saskia Suijkerbuijk as a new group leader! Saskia’s group is interested in how the developmental process Cell Competition regulates tissues in health and disease. As a postdoc in the lab of Eugenia Piddini at the Gurdon Institute (Cambridge – UK), she found that adenomas in the intestine of the fruit fly Drosophila melanogaster use cell competition to drive their growth. When she returned to the Netherlands, she expanded her line of research under the wings of Jacco van Rheenen (Hubrecht Institute and Netherlands Cancer Institute). During this time her group developed 3D co-culture system to model cell competition driven by colorectal cancer in mouse organoids. We are very excited to expand our division with this new line of research and are looking forward to many fruitful collaborations.