Developmental Biology

Van den Heuvel lab



  1. van der Vaart A, Godfrey M, Portegijs V and van den Heuvel. Dose-dependent functions of SWI/SNF BAF in permitting and inhibiting cell proliferation in vivo. Science Advances(2020) May 20.

  2. 2019

  3. Cravo J and van den Heuvel. Tissue polarity and PCP protein function: C. elegans as an emerging model. Curr. Opinion in Cell Biology (2019) Dec 26.

  4. van der Horst SEM, Cravo J, Woollard A, Teapal J, van den Heuvel S. C. elegans Runx/CBFβ suppresses POP-1 TCF to convert asymmetric to proliferative division of stem cell-like seam cells. Development (2019) Nov 18.

  5. Boxem M and van den Heuvel. Cell Polarity: Getting the PARty Started. Current Biology (2019) July 8.

  6. Kipreos ET and van den Heuvel. Developmental Control of the Cell Cycle: Insights from Caenorhabditis elegans . Genetics (2019) Mar 1.

  7. (2018)

  8. Harterink M, Edwards SL, de Haan B, Yau KW, van den Heuvel S, Kapitein LC, Miller KG, Hoogenraad C. Local microtubule organization promotes cargo transport in C. elegans dendrites J. Cell Sci (2018) Oct 22.

  9. Fielmich LE, Schmidt R, Dickinson DJ, Goldstein B, Akhmanova A, Van den Heuvel. Optogenetic dissection of mitotic spindle positioning in vivo. (2018) Aug 15 Elife.

  10. Sugioka K, Fielmich LE, Mizumoto K, Bowerman B, van den Heuvel S, Kimura A, Sawa. Tumor suppressor APC is an attenuator of spindle-pulling forces during C. elegans asymmetric cell division Proc Natl Acad Sci USA (2018) Jan 30.

  11. 2017

  12. Schmidt R, Fielmich LE, Grigoriev I, Katrukha EA, Akhmanova A, van den Heuvel. Two populations of cytoplasmic dynein contribute to spindle positioning in C. elegansembryos J Cell Biol. (2017) Jul 24.

  13. van Rijnberk LM, van der Horst SE, van den Heuvel S, Ruijtenberg S. A dual transcriptional reporter and CDK-activity sensor marks cell cycle entry and progression in C. elegans.PLoS ONE (2017) Feb 12(2).

  14. 2016

  15. Portegijs V, Fielmich LE, Galli M, Schmidt R, Muñoz J, van Mourik T, Akhmanova A, Boxem M van den Heuvel. Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans. PloS Genetics (2016) Oct 6;12(10).

  16. Van der Vaart A, van den Heuvel. Switching on regeneration. Stem Cell Investigation. (2016);3:41.

  17. Waaijers S, Muñoz J, Berends C, Ramalho JJ, Goerdayal SS, Low TY, Zoumaro-Djayoon AD, Hoffmann M, Koorman T, Roderick PT, Harterink M, Seelk S, Kerver J, Hoogenraad CC, Bossinger O, Tursun B, van den Heuvel S, Heck AJR, Boxem. A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. BMC Biology (2016) Aug; 14:66.

  18. Akhmanova A and van den Heuvel. Tipping the spindle into the right position. JCB. (2016) May;213:293-95.

  19. Koorman T, Klompstra D, van der Voet M, Lemmens I, Ramalho JJ, Nieuwenhuize S, van den Heuvel S, Tavernier J, Nance J, Boxem M. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Nat Cell Biol.. (2016) Mar;18(3):337-46.

  20. Harterink M, van Bergeijk P, Allier C, de Haan B, van den Heuvel S, Hoogenraad CC, Kapitein LC. Light-controlled intracellular transport in Caenorhabditis elegans. Curr Biol.. (2016) Feb 22;26(4):R153-4.

  21. Ruijtenberg S, van den Heuvel S. Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression. Cell Cycle. (2016) Jan 17;15(2):196-212.

  22. 2015

  23. Ruijtenberg S, van den Heuvel S. G1/S Inhibitors and the SWI/SNF Complex Control Cell-Cycle Exit during Muscle Differentiation.Cell. (2015) Jul 16;162(2):300-13.

  24. van Schendel R, Roerink SF, Portegijs V, van den Heuvel S, Tijsterman M. Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis.Nat. Commun.(2015) Jun 16;6:(7394).

  25. Maia AF, Tanenbaum ME, Galli M, Lelieveld D, Egan DA, Gassmann R, Sunkel CE, van den Heuvel S, Medema RH. Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1.Sci. Data. (2015) May 12;2:(1500)20.

  26. The I, Ruijtenberg S, Bouchet BP, Cristobal A, Prinsen MB, van Mourik T, Koreth J, Xu H, Heck AJ, Akhmanova A, Cuppen E, Boxem M, Muñoz J, van den Heuvel S. Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells.Nat. Commun. (2015) Jan 6;6:(5906).

  27. Fielmich L-E and Van den Heuvel S. Polarity Control of Spindle Positioning in the C. elegans Embryo. In: Cell Polarity in Development and Disease (Volume 2) Springer, Editor: Klaus Ebnet.

  28. 2013

  29. Waaijers S, Portegijs V, Kerver J, Lemmens BB, Tijsterman M, van den Heuvel S, Boxem M. CRISPR/Cas9-Targeted Mutagenesis in Caenorhabditis elegans.Genetics. (2013) Aug 26.

  30. Berends CW, Muñoz J, Portegijs V, Schmidt R, Grigoriev I, Boxem M, Akhmanova A, Heck AJ, van den Heuvel S. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo.Mol Biol. Cell (2013) Jul;24(14):(2201)-15.

  31. 2012

  32. Van den Heuvel S, Kipreos ET. C. eleganscell cycle analysis.Methods Cell Biol. (2012) 107:265-94.

  33. 2011

  34. Korzelius J, The I, Ruijtenberg S, Prinsen MB, Portegijs V, Middelkoop TC, Groot Koerkamp MJ, Holstege FC, Boxem M, van den Heuvel S. Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells.PLoS Genet. (2011) Nov;7(11).

  35. Wildwater M, Sander N, de Vreede G, van den Heuvel S. Cell shape and Wnt signaling redundantly control the division axis of C. elegans epithelial stem cells.Development. (2011) Oct;138(20):(4375)-85.

  36. Galli M, Muñoz J, Portegijs V, Boxem M, Grill SW, Heck AJ, van den Heuvel S. aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.Nat. Cell Biol. (2011) Aug 21;13(9):(1132)-8.

  37. Korzelius J, The I, Ruijtenberg S, Portegijs V, Xu H, Horvitz HR, van den Heuvel S. C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability.Dev. Biol. (2011) Feb 15;350(2):358-69.

  38. Ruijtenberg S, van den Heuvel S, The I. Regulation of DNA synthesis and replication checkpoint activation during C. elegansdevelopment.InTech Open Access Books. Edited by Jelena Kusic-Tisma. (2011) Sep. ISBN 978-953-307-775-8.

  39. 2010

  40. Kops GJ, van der Voet M, Manak MS, van Osch MH, Naini SM, Brear A, McLeod IX, Hentschel DM, Yates JR 3rd, van den Heuvel S, Shah JV. APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome.J. Cell Sci. (2010) May 15;123(Pt 10):(1623)-33.

  41. 2009

  42. van der Voet M, Lorson MA, Srinivasan DG, Bennett KL, van den Heuvel S. C. elegans mitotic cyclins have distinct as well as overlapping functions in chromosome segregation.Cell Cycle. (2009) Dec 15;8(24):(4091)-102.

  43. Stetak A, Hörndli F, Maricq AV, van den Heuvel S, Hajnal A. Neuron-specific regulation of associative learning and memory by MAGI-1 in C. elegans.PLoS One. (2009) Jun 24;4(6):e(6019).

  44. van der Voet M, Berends CW, Perreault A, Nguyen-Ngoc T, Gönczy P, Vidal M, Boxem M, van den Heuvel S. NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Gα.Nat. Cell Biol. (2009) Mar;11(3):269-77.

  45. 2008

  46. van den Heuvel S, Dyson NJ. Conserved functions of the pRB and E2F families.Nat. Rev. Mol. Cell Biol. (2008) Sep;9(9):713-24.

  47. Galli M, van den Heuvel S. Determination of the cleavage plane in early C. elegans embryos.Annu. Rev. Genet. (2008) Vol. 42:389-411.

  48. Boxem M, Maliga Z, Klitgord N, Li N, Lemmens I, Mana M, de Lichtervelde L, Mul JD, van de Peut D, Devos M, Simonis N, Yildirim MA, Cokol M, Kao HL, de Smet AS, Wang H, Schlaitz AL, Hao T, Milstein S, Fan C, Tipsword M, Drew K, Galli M, Rhrissorrakrai K, Drechsel D, Koller D, Roth FP, Iakoucheva LM, Dunker AK, Bonneau R, Gunsalus KC, Hill DE, Piano F, Tavernier J, van den Heuvel S, Hyman AA, Vidal M. A protein domain-based interactome network for C. elegansearly embryogenesis.Cell. (2008) Aug 8;134(3):534-45.

  49. Clayton JE, van den Heuvel SJ, Saito RM. Transcriptional control of cell-cycle quiescence during C. elegans development.Dev. Biol. (2008) Jan 15;313(2):603-13.

  50. 2007

  51. Korzelius J, van den Heuvel S. Replication licensing: oops! ... I did it again.Curr. Biol. (2007) Aug 21;17(16):R630-2.

  52. Wildwater M, The I, van den Heuvel S. Coordination of cell proliferation and differentiation: finding a GEM in the root?Dev. Cell. (2007) Jun;12(6):841-2.

  53. Ceron J, Rual JF, Chandra A, Dupuy D, Vidal M, van den Heuvel S. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.BMC Dev. Biol. (2007) Apr 6;7:30.

  54. 2006

  55. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.Nature. (2006) Aug 10;442((7103)):700-4.

  56. Shirayama M, Soto MC, Ishidate T, Kim S, Nakamura K, Bei Y, van den Heuvel S, Mello CC. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans.Curr. Biol. (2006) Jan 10;16(1):47-55.

  57. 2005

  58. van den Heuvel S. Cell-cycle regulation.WormBook. (2005) Sep 21:1-16.

  59. Koreth J, van den Heuvel S. Cell-cycle control in Caenorhabditis elegans: how the worm moves from G1 to S.Oncogene. (2005) Apr 18;24(17):(2756)-64.

  60. van den Heuvel S. The C. elegans cell cycle: overview of molecules and mechanisms.Methods Mol. Biol. (2005) Vol. 296:51-67.

  61. 2004

  62. Rual JF, Ceron J, Koreth J, Hao T, Nicot AS, Hirozane-Kishikawa T, Vandenhaute J, Orkin SH, Hill DE, van den Heuvel S, Vidal M. Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library.Genome Res. (2004) Oct;14(10B):(2162)-8.

  63. Miley GR, Fantz D, Glossip D, Lu X, Saito RM, Palmer RE, Inoue T, Van Den Heuvel S, Sternberg PW, Kornfeld K. Identification of residues of the Caenorhabditis elegans LIN-1 ETS domain that are necessary for DNA binding and regulation of vulval cell fates.Genetics. (2004) Aug;167(4):(1697)-709.

  64. Saito RM, Perreault A, Peach B, Satterlee JS, van den Heuvel S. The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans.Nat. Cell Biol. (2004) Aug;6(8):777-83.

  65. Zhang H, Christoforou A, Aravind L, Emmons SW, van den Heuvel S, Haber DA. The C. elegans Polycomb gene sop-2 encodes an RNA binding protein.Mol. Cell. (2004) Jun 18;14(6):841-7.

  66. Fisk Green R, Lorson M, Walhout AJ, Vidal M, van den Heuvel S. Identification of critical domains and putative partners for the Caenorhabditis elegans spindle component LIN-5.Mol. Genet. Genomics. (2004) Jun;271(5):532-44.

  67. Zhang H, Smolen GA, Palmer R, Christoforou A, van den Heuvel S, Haber DA. SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2.Nat. Genet. (2004) May;36(5):507-11.

  68. van den Heuvel S. Protein degradation: CUL-3 and BTB—partners in proteolysis.Curr. Biol. (2004) Jan 20;14(2):R59-61.

  69. *Li S, *Armstrong CM, *Bertin N, *Ge H, *Milstein S, *Boxem M, *Vidalain PO, *Han JD, *Chesneau A, Hao T, Goldberg DS, Li N, Martinez M, Rual JF, Lamesch P, Xu L, Tewari M, Wong SL, Zhang LV, Berriz GF, Jacotot L, Vaglio P, Reboul J, Hirozane-Kishikawa T, Li Q, Gabel HW, Elewa A, Baumgartner B, Rose DJ, Yu H, Bosak S, Sequerra R, Fraser A, Mango SE, Saxton WM, Strome S, Van Den Heuvel S, Piano F, Vandenhaute J, Sardet C, Gerstein M, Doucette-Stamm L, Gunsalus KC, Harper JW, Cusick ME, Roth FP, Hill DE, Vidal M. A map of the interactome network of the metazoan C. elegans.Science. (2004) Jan 23;303((5657)):540-3.
    *These authors contributed equally.

  70. Van den Heuvel S. The C. eleganscell cycle: overview of molecules and mechanisms.In: Methods in Molecular Biology. Edited by G Brooks and T Humphry, Humana Press, Inc. (2004) Vol 296, Cell Cycle Control, Mechanisms and Protocols. 51-67.

  71. 2003

  72. Srinivasan DG, Fisk RM, Xu H, van den Heuvel S. A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans.Genes Dev. (2003) May 15;17(10):(1225)-39.

  73. Yajnik V, Paulding C, Sordella R, McClatchey AI, Saito M, Wahrer DC, Reynolds P, Bell DW, Lake R, van den Heuvel S, Settleman J, Haber DA. DOCK4, a GTPase activator, is disrupted during tumorigenesis.Cell. (2003) Mar 7;112(5):673-84.