Our goal is to identify novel gene regulatory mechanisms of tissue-tissue interaction using embryo models
We aim to dissect the physical and biochemical interaction between different organ primordia during mammalian embryonic development. We use stem cell-based embryo models (such as gastruloids) together with (single-cell) genomics, advanced microscopy, and reporter assays to study how gene regulation drives inter-tissue communication. Understanding the cross-talk between developing organs is a milestone towards the generation of organs in vitro for regenerative medicine.