Developmental Biology

a worm

Two Positions Available

PhD/Postdoc Position: Single cell analysis of cell differentiation in vivo (1.0 FTE)

The Van den Heuvel lab invites applications for a PhD or postdoctoral research position in Developmental Biology. The focus of the project will be to reveal the regulatory logic of cellular decision making in the context of animal development. Specifically, we seek to better understand how precursor cells commit to a specialized cellular fate, and how this is coordinated with a permanent arrest of cell division. To address these questions, we will perform detailed quantitative analyses of native cells during their differentiation trajectory in the round worm Caenorhabditis elegans (C. elegans). This project will incorporate the latest technologies in transcriptome, epigenome, and proteome analysis, and will be carried out in close collaboration with specialists in computational modeling (ten Tusscher lab, UU), single-cell analysis (Korswagen and van Oudenaarden labs, Hubrecht Institute), and proteomics techniques (Vermeulen lab, Radboud University Nijmegen).

More information about the open position you find here .

PhD position: Live-imaging of mRNA and protein expression regulation (1.0 FTE)

The newly established research group of Dr Suzan Ruijtenberg at Utrecht University invites applications for a PhD position in Developmental Biology. The focus of the project is to visualize and understand when and where individual proteins are synthesized and how changes in translation efficiencies affect cell fate and organismal behaviour. To address these questions, a combination of genetic, biochemical and single molecule imaging approaches in the round worm Caenorhabditis elegans (C. elegans) will be used (Ruijtenberg et al., Methods in Molecular Biology, 2018, Ruijtenberg et al., Bioxriv, 2019). In addition, the project will involve developing new, innovative imaging and labeling technologies which allows visualization and regulation of gene expression dynamics. This effort is part of the Developmental Biology programme at Utrecht University, and will be carried out in close collaboration with Researchers in the Boxem and Van den Heuvel labs, as well as other Researchers within the Institute of Biodynamics and Biocomplexity (IBB) at Utrecht University (e.g. Akhmanova, Kapitein labs). This collaborative environment makes it possible to apply the latest technologies (CRISPR, live-imaging) and use state-of-the-art microscopy facilities, and (single-cell) RNA/DNA sequencing platforms (single-cell Discoveries, USEQ).

More information about the open position you find here .