Departement Biologie: Microbiology

<body> <a name="_Top"> </a> <table id="main" width="880" border="0" cellspacing="0" cellpadding="0" summary="Content"> <tr> <td valign="top" height="250" width="36"></td> <td valign="top" id="content" width="840"> <h2>Research</h2> <p style="line-height: 150%">Research in the group of Microbiology focuses on <span lang="EN-US">understanding the mechanisms involved in secretion of proteins and the role of secreted proteins in bacterial membrane biogenesis and fungal growth and development. Prof. Dr. H.A.B. Wösten is head of the fungal group. Prof. Dr. J.P.M. Tommassen is head of the bacterial group. Fungal Physiology is a collaboration with the CBS Fungal Biodiversity Centre and is headed by Dr. ir. R.P. de Vries.</span></p> <h3><font color="#990033"><a href="bacteria/research/index.html">Bacterial group</a></font></h3> <p><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size: 12.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA"><img border="0" src="images/DSC04821_res.jpg" style="border-style: solid" width="223" height="195"> <img border="0" src="images/r-mix.gif" width="193" height="195" style="text-align: Left; word-spacing: 0; text-indent: 0; line-height: 150%; margin: 0"> <img border="0" src="images/DD3696_contr_res.jpg" width="228" height="195"></span></p> <p><span style="mso-bidi-font-size: 12.0pt; mso-fareast-font-family: Times New Roman; mso-bidi-font-family: Times New Roman; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA" lang="EN-US"><font face="Arial Narrow" color="#000000" size="1">Picture center, source: R.Hubert, Program in Microbiology, Iowa State University</font></span></p> <p style="line-height: 150%"><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size: 12.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">The research program of the bacterial group studies cell envelope-related processes in Gram-negative bacteria and focuses on three lines: </span></p> <p style="line-height: 150%"><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size: 12.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA"> 1) biogenesis of the bacterial outer membrane</span></p> <p style="line-height: 150%"><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size: 12.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">2) protein secretion</span></p> <p style="line-height: 150%"><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size: 12.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">3) vaccine development</span></p> <h3><font color="#990033"><a href="fungi/research/index.html">Fungal group</a></font></h3> <p><img border="0" src="images/schizophyllum_commune_resized_2.jpeg" width="256" height="195"> <img border="0" src="images/colonia_340x_bf_res.jpg" width="261" height="195"> <img border="0" src="images/dd100umB_res.jpg" width="226" height="195"> </p> <p style="line-height: 150%"><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size: 12.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">The research program of the fungal group focuses on </span></p> <p style="line-height: 150%"><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size: 12.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA"> 1) the location of production and secretion of proteins in fungi </span></p> <p style="line-height: 150%"><span lang="EN-US" style="font-size:10.0pt;mso-bidi-font-size: 12.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA"> 2) the role of secreted proteins in pathogenicity and the formation of reproductive structures</span></p> <h3 style="line-height: 150%"><font color="#990033"><a href="fungi/fungal%20physiology/index.html">Fungal physiology</a> <img border="0" src="images/cbs_logo_res.jpg" width="80" height="48"></font></h3> <p style="line-height: 150%"><img border="0" src="images/pellets_res.jpg" width="261" height="195"> <img border="0" src="images/Wheat_Bran_pellets_res.jpg" width="261" height="195"> <img border="0" src="images/beechwood_xylan_res.jpg" width="196" height="195"></p> <p style="line-height: 150%"><span style="font-size: 10.0pt; mso-bidi-font-size: 12.0pt; font-family: Verdana; mso-fareast-font-family: Times New Roman; mso-bidi-font-family: Times New Roman; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA" lang="EN-US">The research program of Fungal Physiology focuses on utilization of natural carbon sources with special emphasis on:</span></p> <p style="line-height: 150%"><span style="font-size: 10.0pt; mso-bidi-font-size: 12.0pt; font-family: Verdana; mso-fareast-font-family: Times New Roman; mso-bidi-font-family: Times New Roman; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA" lang="EN-US">1. Regulatory systems<br> 2. Polysaccharide degradation<br> 3. Metabolic pathways</span></p> <p> </p> </td> </tr> <tr> <td height="50" width="36"></td> <td align="left" valign="bottom" width="840"> <div class="teklein"><a target="_self" href="#_Top"> <img border="0" src="images/solis/pijl-up.gif" align="right" width="25" height="28" /></a><a href="cnt.html" target="_self"> </a> Last update: 10-mrt-2011<br /> <a href="mailto:j.f.dejong@bio.uu.nl">j.dejong@uu.nl</a></div> </td> </tr> <tr> <td width="36"><img src="images/tpix.gif" width="36" height="1" alt="" /></td> <td width="840"><img src="images/tpix.gif" width="714" height="1" alt="" /></td> </tr> </table>  </body>